Genetics Concentration » Graduate Program in Biomedical Sciences » College of Medicine » University of Florida


NOTE: This page is for detailed information about the Genetics Advanced Concentration only. All inquiries concerning admission to the BMS Admissions office at biomed@med.ufl.edu. More information on admissions is also available on the Admissions Page.

Overview

The Advanced Concentration in Genetics is one of eight advanced concentrations leading to the Ph.D. degree under the auspices of the Graduate Program ( BMS ) in biomedical Sciences at the University of Florida College of Medicine .
Genetics is the footing for all of biology and is the most quickly evolving field in biomedical research, applicable from the most dim-witted organism to humans. Genetics can include plainly using tools to manipulate nucleic acids or employing a genetic scheme to develop and test hypotheses and translational resources. In our concentration, the goal is to use genetics to advance agreement of disease processes and potential therapies. about 70 staff are affiliated with the concentration, from six colleges, providing broad opportunities for graduate coach involving genetics .
The Genetics concentration is highly compromising, allowing students/mentors to wholly tailor all optional coursework, lab train, and other opportunities ( e.g. professional development, community service, education, collaboration ) for each student ’ s undertaking and long-run goals. There are no specific required courses, and students may choose to take a different journal baseball club in the spring of each year, to personalize their focus of study. Any grade diary clubs will count toward the coursework requirement after the first year.

With genetics and genomics being omnipresent, Genetics dissertation projects are highly divers and interdisciplinary. thus, our students graduate with a depth of skills and approaches that allow them to successfully pursue a variety show of career paths. Because many of our students have chosen the biotechnology/pharmaceutical path, our concentration has been given access to local biotechnology companies via an annual secret tour, to learn firsthand about the facets of private industry, specific companies, and to make connections

 

Areas of Research

  • Gene therapy
  • Vector development
  • Pharmacogenetics
  • Animal models of disorders and physiological systems
  • Cancer genetics and biology
  • Human genetics – Mendelian and multifactorial traits
  • Bioinformatics/computational biology
  • Structure/function mutation pathogenesis studies
  • Prokaryotic genetics
  • Development
  • Viral pathogenesis
  • Noncoding RNA in disease
  • Epigenetics and genetic imprinting
  • Stem cells and iPS cells in development and disease

Learn about the UF Center for NeuroGenetics .
Laura Ranum, Ph.D., Director of Center for NeuroGenetics

Program of Study

Year One

Fall Semester Spring Semester
BMS Required Courses BMS Required Courses
GMS 6001: Fundamentals of Biomedical Research, 5 credit hours GMS 7877: Responsible Conduct of Biomedical Research, 1 credit hour
GMS 6003: Essentials of Graduate Research & Professional Development, 1 credit hour GMS 6090: Rotation #3, 1 credit hour
GMS 6090: Rotation #1, 1 credit hour GMS 6895: Journal Club, 1 credit hour
GMS 6090: Rotation #2, 1 credit hour Plus 6 hours of coursework: Based on discussion with potential mentors, other advisors and interest for thesis project. Examples of recommended spring first-year courses:
GMS 6895: Journal Club, 1 credit hour GMS 6012: Human Genetics
For students entering the program with a relevant Master’s degree, exceptions to the first semester curriculum may be granted with transfer of credit for equivalent coursework. GMS 6014: Applications of Bioinformatics to Genetics
BCH 6415: Advanced Molecular and Cell Biology
GMS 6065: Cancer Biology
GMS 6034-6: One or more of three 1-credit courses in Advanced Virology
GMS 6140: Principles of Immunology
One or more of 1-credit courses in Molecular Therapy

Beyond the First Year: Students must earn > 6 calibrate credits in courses, which can include graduate credits transferred in with permission of concentration co-directors. many Genetics students opt to take more than 6 run credits after the beginning year, and/or complete a minor or certificate program .
—GMS 6920 Genetics Journal Club ( 1 credit ) in the fall of every year, with option to take a different journal club in the spring semesters .
—All graduate grade Statistics and Biostatistics are acceptable, and any UF graduate-level courses not in the BMS course of study list can be brought to the assiduity co-directors for approval .
Courses most normally chosen by genetics students :
Human Genetics II ( GMS 6015 )
Epigenetics of Human Disease and Development ( BCH 7412 )
Advanced Gene Regulation ( BCH 7410 )
special Topics : RNA Interference and MicroRNAs ( GMS 5905 )
Fundamentals of Biomedical Science Education ( GMS 7950 )
Advanced Applications of Bioinformatics ( GMS 6232 )
familial Model Systems ( GMS 6151 )
Stem Cell Biology ( GMS 6331 )
signal Transduction ( GMS 6051 )
Mitochondrial Biology in Aging and Disease ( GMS 6622 )
Mechanisms of Aging ( GMS 6063 )
late Advances in Cancer Metastatis ( GMS 6338 )
Advanced Stem Cell Biology : weave Engineering ( GMS 6335 )
stream Topics in Vision ( GMS 6790 )
Summer Option: GMS 5905 Special Topics : Genetics Grant Writing ( 1 credit ) typically taken after the end of the 2nd year, to prepare for the Qualifying Exam written marriage proposal. This is a grade 1-credit course that counts toward the coursework necessity .
All grad level Statistics and Biostatistics courses are satisfactory ; graduate courses not listed in the BMS course of study must be brought to the co-directors for blessing .
Most genetics students take at least half of the 6 credits in the second base year, but they can be spread throughout the aim angstrom well.

Read more: Thesis – Wikipedia

The Faculty and Their Research

For a tilt of staff members in the Genetics boost course of study, please cluck here .
Meet Eric Wang, Ph.D. and learn about his research in RNA regulation .

Alumni Spotlight

Meet Dr. Angela McCall, a 2017 Genetics Concentration graduate :

Student Outcomes

Over the 20 years of this program, our concentration has graduated over 100 PhDs, with an average of 1.8 beginning author papers and 2.2 co-authorships. Students have successfully competed for fellowships from the NIH, American Heart Association and UF ’ s Clinical and Translational TL1 program. In addition, students often gain positions on UF Health Science Center prepare grants. Students who are awarded an person family receive a bonus for each semester he/she holds the award .
Based on students from the first 15 years of the course of study, career distribution is : 63 % academia ( tenure track and non-tenure track ), 20 % private diligence, 7 % federal positions ( CDC, NIH, FDA, etc ), 10 % other ( e.g. science law, clinical inquiry, clinical lab director, science policy, skill clientele administration, non-profit foundations ) .

What We’re Publishing

Somatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque.
McCullough KT, Boye SL, Fajardo D, Calabro K, Peterson JJ, Strang CE, Chakraborty D, Gloskowski S, Haskett S, Samuelsson S, Jiang H, Witherspoon CD, Gamlin PD, Maeder ML, Boye SE. Hum Gene Ther. 2019 May;30(5):571-589. doi: 10.1089/hum.2018.193. 
Downregulation of the human peripheral myelin protein 22 gene by miR-29a in cellular models of Charcot-Marie-Tooth disease.
Serfecz J, Bazick H, Al Salihi MO, Turner P, Fields C, Cruz P, Renne R, Notterpek L. Gene Ther. 2019 Aug 27. doi: 10.1038/s41434-019-0098-z.
Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation.
Denes LT, Riley LA, Mijares JR, Arboleda JD, McKee K, Esser KA, Wang ET. Skelet Muscle. 2019 Jun 7;9(1):17. doi: 10.1186/s13395-019-0203-4.
Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal-Dominant Retinal Disorders.
Massengill MT, Young BM, Lewin AS, Ildefonso CJ. Methods Mol Biol. 2019;1937:235-258. doi: 10.1007/978-1-4939-9065-8_15.
A mouse model of Angelman syndrome imprinting defects.
Lewis MW, Vargas-Franco D, Morse DA, Resnick JL. Hum Mol Genet. 2019 Jan 15;28(2):220-229. doi: 10.1093/hmg/ddy345. Mol Ther. 2018 Oct 3;26(10):2407-2417. doi: 10.1016/j.ymthe.2018.07.016. Epub 2018 Jul 19.
Associations of P2RX7 Functional Diplotypes with Localized Aggressive Periodontitis
Harris TH, Wallace MR, Huang H, Li H,  Shaddox LM.  Association of P2RX7 functional diplotypes with localized aggressive periodontitis.  JDR Clinical and Translational Research. 2019. Oct;4(4):342-351.  doi: 10.1177/2380084419863789.    
Retinal homeostasis and metformin-induced protection are not affected by retina-specific Ppard knockout.
Xu L, Brown Eem, Santiago CP, Keuthan CJ, Lobanova E, Ash JD.  Retinal homeostasis and metformin-induced protection are not affected by retina-specific Ppard knockout. Redox Biol. 2020. Aug 25:101700.  doi: 10.1016/j.redox.2020.101700.
Computational analysis of ribonomics datasets identifies long non-coding RNA targets of gamma-herpesviral miRNAs.
Sethuraman S, Thomas M, Gay LA, Renne R.  Computational analysis of ribonomics datasets identifies long non-coding RNA targets of gamma-herpesviral miRNAs.  Nucleic Acids Res. 2018. Sep 19;46(16):8574-8589.  doi: 10.1093/nar/gky459.

Margaret ( Peggy ) Wallace, Ph.D.
Coordinator, Genetics Advanced Concentration
Department of Molecular Genetics and Microbiology
peggyw @ mgm.ufl.edu | ( 352 ) 392-3055
Lei Zhou, Ph.D.
Co-Coordinator, Genetics Advanced Concentration
Department of Molecular Genetics and Microbiology
leizhou @ ufl.edu | ( 352 ) 273-8169
Kris Minkoff
Graduate Administrator
call : ( 352 ) 273-6380 | Email : MGM-GradEd @ mgm.ufl.edu

 

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